It has only very weak effects on norepinephrine and dopamine reuptake.
Chornic administration of sertraline is thought to down-regulate norepinephrine receptors.
6歳以下は推奨されず

Indication

6〜17歳【強迫性障害にのみ適応】

25〜200mg daily 日本の保険適応は100mgまで
Because of sertaline`s relatively long（24-hr）elimination half-life,titration based on clinical response is recommended at intervals of at least 7 days to permit adequate assessment of clinical response at a given dosase

18歳以上

• MDD and OCD
• Panic disorder,PTSD,Social Anxiety Disorder
• Premenstual Dysphoric Disorder

Untoward Effects

• Nausea
• Insomia
• Diarrhea
• Ejaculatory delay
• Somnolence